Compare funds
IBB and SBIO share 66 stocks, about 10% of IBB and 84% of SBIO (10.5% overlap by weight). Expense ratios: IBB 0.44%, SBIO 0.50%.
At a glance
Expense ratio = the yearly fee, as a share of your money in the fund. The lowest is marked.
| IBB | SBIO | |
|---|---|---|
| Fund | iShares Biotechnology ETF | ALPS Medical Breakthroughs ETF |
| Expense ratio | 0.44%Lowest | 0.50% |
| Yearly cost on $10,000 | $44.00 | $50.00 |
| Holdings | 248 | 82 |
| Top 10 holdings | 44.7% | 34.8% |
| Net assets | $9.1B | $161.8M |
| Holdings as of | Jun 30, 2026 | May 31, 2026 |
| Prospectus filed | Jul 27, 2026 | Mar 30, 2026 |
Past returns
Price change plus dividends. “Per year” rows are yearly averages. The highest in each row is in navy.
| IBB | SBIO | |
|---|---|---|
| 1 week | — | — |
| 1 month | — | — |
| 3 months | — | — |
| 6 months | — | — |
| Year to date | — | — |
| 1 year | — | — |
| 3 years, per year | — | — |
| 5 years, per year | — | — |
| Since start of price data, per year | — | — |
Through —. A dash means the fund is younger than the period. Past returns don’t predict future returns.
Shared holdings
Largest first, by the smaller of the funds’ weights.
| Holding | IBB | SBIO |
|---|---|---|
Alkermes plcALKS | 0.67% | 4.48% |
Kymera Therapeutics, Inc.KYMR | 0.64% | 4.23% |
Apogee Therapeutics, Inc. | 0.59% | 2.93% |
Spyre Therapeutics, Inc.SYRE | 0.54% | 3.68% |
Mirum Pharmaceuticals, Inc.MIRM | 0.45% | 3.90% |
Xenon Pharmaceuticals, Inc.XENE | 0.43% | 2.90% |
Travere Therapeutics, Inc.TVTX | 0.40% | 2.77% |
Oruka Therapeutics, Inc.ORKA | 0.38% | 1.81% |
ACADIA Pharmaceuticals, Inc.ACAD | 0.33% | 2.35% |
CG oncology, Inc.CGON | 0.32% | 3.35% |
Denali Therapeutics, Inc.DNLI | 0.30% | 2.13% |
Crinetics Pharmaceuticals, Inc. | 0.29% | 2.37% |
Edgewise Therapeutics, Inc.EWTX | 0.25% | 2.33% |
Structure Therapeutics, Inc.GPCR | 0.24% | 1.78% |
Ideaya Biosciences, Inc.IDYA | 0.24% | 1.65% |
Newamsterdam Pharma Co NvNAMS | 0.21% | 2.47% |
Relay Therapeutics, Inc.RLAY | 0.21% | 1.60% |
Tarsus Pharmaceuticals, Inc.TARS | 0.20% | 1.61% |
Vera Therapeutics, Inc., Class AVERA | 0.20% | 1.61% |
Vericel Corp.VCEL | 0.18% | 1.08% |
Top 20 of 66 shared holdings.
Only in IBB
173 holdings, 89.4% of the fund.
Only in SBIO
16 holdings, 16.3% of the fund.
How this works & disclosures
Holdings come from each fund’s latest public Form N-PORT on SEC EDGAR (as-of dates in the table), so they can be a few months old.
Expense ratios come from the fee table in each fund’s prospectus (Form 485BPOS) on SEC EDGAR, read from its XBRL data; a dash means it wasn’t machine-readable there, so check the prospectus. Yearly cost on $10,000 is simple arithmetic: expense ratio × $10,000, before any change in the fund’s value.
Returns use Yahoo Finance daily closes (15-min delayed source) adjusted for dividends and splits, so dividends are included as if reinvested. 3Y, 5Y and since-start figures are annualized (yearly averages). “Since start” begins on the first day our price source has for the fund; funds that started on different dates aren’t directly comparable. The growth chart is hypothetical, with no taxes or trading costs.
Overlap by weight adds up, for every holding both funds own, the smaller of its two weights. Shared stocks are matched by ticker, ISIN, CUSIP or name.
Data from SEC Form N-PORT, the holdings report funds file with the SEC each quarter; the SEC makes it public about 60 days after the quarter ends. Holdings change; this may be out of date. SURVYR. describes what funds hold and how they have done; it does not manage money or give advice. Not investment advice. Full disclosures
Data from SEC filings. Holdings change; this may be out of date. Not investment advice. Disclosures
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Systematic research · Not investment advice · Hypothetical unless marked Live · Data: Yahoo Finance (15-min delayed), SEC EDGAR, House Clerk · Important disclosures · Contact desk@coteau.app
Coteau 0.9 · Oct 21, 2026